SCCmec

International Working Group on the Staphylococcal Cassette Chromosome elements (IWG-SCC)

Review of the methods

  • Tetsuo Yamaguchi, Daisuke Ono, and Ayami Sato (2020) Staphylococcal Cassette Chromosome mec (SCCmec) Analysis of MRSA
    • In: Yinduo Ji (ed.), Methicillin-Resistant Staphylococcus Aureus (MRSA) Protocols: Cutting-Edge Technologies and Advancements, Methods in Molecular Biology, vol. 2069, https://doi.org/10.1007/978-1-4939-9849-4_4

PCR-based methods

  • Zhang K, McClure JA, Elsayed S, Louie T, Conly JM. (2005)

Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus. J Clin Microbiol 43(10):5026-5033

  • Kondo Y, Ito T, Ma XX, Watanabe S, Kreiswirth BN, Etienne J et al. (2007)

Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions. Antimicrob Agents Chemother 51(1):264–274

  • Milheirico C, Oliveira DC, de Lencastre H (2007)

Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: ‘SCCmec IV multiplex’. J Antimicrob Chemother  60(1):42-48

Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus. Antimicrob Agents Chemother 51(9):3374–3377

  • Zhang K, McClure JA, Conly JM (2012)

Enhanced multiplex PCR assay for typing of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus. Mol Cell Probes 26(5):218–221

WGS-based method

  • SCCmec Finder
  • Reference
    • Kaya H, Hasman H, Larsen J, Stegger M, Johannesen TB, Allesoe RL et al (2018) SCCmecFinder, a web-based tool for typing of staphylococcal cassette chromosome mec in Staphylococcus aureus using whole-genome sequence data. mSphere 3(1). https://doi.org/10.1128/mSphere.00612-17

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